Searches for exploitable biochemical differences between normal and cancer cells. IX. Anabolism and catabolism of purines by hepatomas 5123 and H-35.

Searches for exploitable biochemical differences between normal and cancer cells. VII. Anabolism and catabolism of purines by minced tissues.

Minced neoplasms and minced tissues of the host animals were incubated with xanthine-8-C 14, hypoxanthine-8-C 14, adenine-8-C 14, or guanine-8-C~4; and aqueous alcoholic extracts of these mixtures were examined by means of the chromatographicradioautographic technic. I t was found that relatively less catabolism and more anabolism occurred in the neoplastic tissues than in most of the host tiss...

Searches for exploitable biochemical differences between normal and cancer cells. X. Catabolism of purines by regressing tumors.

The in vitro anabolism and catabolism of radioactive purities by minces and of radio active purines and purine ribonucleotides by sonicates of growing and regressing tu mors were investigated with the aid of paper chromatography, radioautography, and radioassay. Two systems of growing and regressing tumors were used: (a) cyclophosphamide-sensitive and cyclophosphamide-resistant plasmacytomas gr...

Searches for Expbitable Biochemical Differences between Normal and Cancer Cells VII. Anabolism and Catabolism of Purines by Minced Tissues*

Minced neoplasms and minced tissues of the host animals were incubated with xanthine-8-C 14, hypoxanthine-8-C 14, adenine-8-C 14, or guanine-8-C~4; and aqueous alcoholic extracts of these mixtures were examined by means of the chromatographicradioautographic technic. I t was found that relatively less catabolism and more anabolism occurred in the neoplastic tissues than in most of the host tiss...

Searches for exploitable biochemical differences between normal and cancer cells. II. Nucleic acid purine metabolism in human tumors.

The comparative enzymology and cell origin of rat hepatomas. I. Deoxycytidylate deaminase and thymine degradation.

Enzyme assays for deoxycytidylate deaminase and thymine catabolism were carried out on ten rat hepatomas, including the Novikoff, Dunning L-C18, McCoy MDAB, and the Morris 3683, 3924A, and 5128 hepatomas, plus primary hepatomas produced by feeding ethionine or 8'-methyl-4-dimethylaminoazobenzene, and hepatomas derived from the primary tumors induced with ethionine. Normal liver, Dunning L-C18 h...